Acute effects of THC on time perception in frequent and infrequent cannabis...
AbstractRationaleCannabinoids have been shown to alter time perception, but existing literature has several limitations. Few studies have included both time estimation and production tasks, few control...
View ArticleEffects of Δ9-tetrahydrocannabinol in individuals with a familial...
AbstractBackground and aimsA family history (FH) of alcoholism accounts for approximately 50 % of the risk of developing alcohol problems. Several lines of preclinical evidence suggest that brain...
View ArticleRelationships between impulsivity and subjective response in an IV ethanol...
AbstractRationaleImpulsivity and individual differences in subjective response to alcohol are risk factors for alcohol problems and possibly endophenotypes for alcohol dependence. Few prior studies...
View ArticleHyperinsulinemia and elevated systolic blood pressure independently predict...
AbstractCerebrovascular disease is an independent risk factor for dementia that may also be synergistic with Alzheimer’s disease. In recent years attention has switched from cerebral infarcts to...
View ArticleComparison of focused cognitive training and portable “brain-games” on...
AbstractCognitive remediation performed in a cognitive laboratory was compared with a sham control using portable brain games to study effects on vocational, neurocognitive, and functional outcomes for...
View ArticleThe effects of cannabidiol (CBD) on cognition and symptoms in outpatients...
AbstractRationalePreliminary evidence suggests that cannabidiol (CBD) may be effective in the treatment of neurodegenerative disorders; however, CBD has never been evaluated for the treatment of...
View ArticleEffects of age, BMI and sex on the glial cell marker TSPO — a multicentre...
AbstractPurposeThe purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission...
View ArticleHighs and lows of cannabinoid-dopamine interactions: effects of genetic...
AbstractRationaleThe catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human...
View ArticlePersonality as a mediator of autistic traits and internalizing symptoms in...
AbstractBackgroundAutism spectrum disorder (ASD) is characterized by deficits in social functioning and is comorbid with internalizing disorders and symptoms. While personality is associated with these...
View ArticleSex differences in the acute effects of intravenous (IV) delta-9...
Abstract BackgroundCannabis is the most common illicit drug used in the USA and its use has been rising over the past decade, while the historical gap in rates of use between men and women has been...
View ArticlePreliminary study of the interactive effects of THC and ethanol on...
Abstract RationaleDrug- and alcohol-related motor vehicle accidents are a leading cause of morbidity and mortality worldwide. Compared to alcohol, less is known about the effects of cannabis on driving...
View ArticleThe regional pattern of age-related synaptic loss in the human brain differs...
AbstractPurposeAging is a major societal concern due to age-related functional losses. Synapses are crucial components of neural circuits, and synaptic density could be a sensitive biomarker to...
View ArticleImaging Nicotine- and Amphetamine-Induced Dopamine Release in Rhesus Monkeys...
AbstractThe radiotracer [11C]PHNO may have advantages over other dopamine (DA) D2/D3 receptor ligands because, as an agonist, it measures high-affinity, functionally active D2/D3 receptors, whereas the...
View ArticleΔ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans
AbstractGamma (γ)-band oscillations play a key role in perception, associative learning, and conscious awareness and have been shown to be disrupted by cannabinoids in animal studies. The goal of this...
View ArticleRole of GABA Deficit in Sensitivity to the Psychotomimetic Effects of...
AbstractSome schizophrenia patients are more sensitive to amphetamine (AMPH)-induced exacerbations in psychosis–an effect that correlates with higher striatal dopamine release. This enhanced...
View ArticleElevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET...
AbstractMost prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D2/3R) non-selective antagonist tracers suggests that obese (OB) individuals exhibit lower D2/3Rs when...
View ArticleSocial status and demographic effects of the kappa opioid receptor: a PET...
AbstractKappa opioid receptors (KORs) have been characterized as an aversive system in the brain and implicated in social behavior in preclinical models. This work investigated the effect of social...
View ArticleInfluence of combined treatment with naltrexone and memantine on alcohol...
AbstractGlutamate and opioid systems play important roles in alcohol drinking behaviors. We examined if combined treatment with the NMDA antagonist memantine and the opioid antagonist naltrexone, when...
View ArticleGraph theory analysis of whole brain functional connectivity to assess...
AbstractBrain targets to lower the high risk of suicide in Bipolar Disorder (BD) are needed. Neuroimaging studies employing analyses dependent on regional assumptions could miss hubs of dysfunction...
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